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Omeprazole for Dogs: An Antacid to Soothe Your Dog’s Stomach

Dr. Julie Buzby July 28, 2022 38 Comments

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Omeprazole for dogs can be a great solution for a variety of dog digestive problems. Integrative veterinarian Dr. Julie Buzby explains the uses, side effects, and precautions for omeprazole so you will be prepared should your dog ever need it.

Smiling, happy dog sitting on a bed as if feeling better from dog digestive issue

If you suffer from heartburn, you probably keep a steady supply of your favorite over-the-counter antacid medication within reach. But did you know that dogs can benefit from antacids too? Unlike you, they probably won’t be getting heartburn from tomato sauce or spicy food. But dogs with conditions like stomach inflammation or gastrointestinal ulcers can certainly benefit from an antacid such as omeprazole.

What is omeprazole for dogs?

If you are familiar with human antacids, you have probably heard of Prilosec®. This is the brand name (i.e. trade name) for the antacid drug omeprazole. While there is a form of omeprazole labeled for use in horses (brand names: GastroGard®, UlcerGard®, etc.), there isn’t one for dogs and cats. This means that veterinarians will use the human version of omeprazole in an off-label fashion for dogs. Don’t worry though—veterinarians safely use many human drugs off-label on a regular basis.

Most commonly, veterinarians use omeprazole to treat intestinal and stomach ulcers in dogs. They may also prescribe it for patients with acute inflammation of the stomach and those with Helicobacter spp. infections. It is useful for those conditions because of its ability to block stomach acid production.

How does it work?

Some antacids work by making stomach acid less acidic. For example, the calcium carbonate in Tums® is very alkaline while stomach acid is very acidic. (Think back to the pH scale you learned about in high school chemistry). When the alkaline calcium carbonate meets the acidic stomach acid, the pH of the fluid in the stomach becomes closer to neutral. This is helpful because it can make an upset stomach feel better.

Omeprazole takes it one step further though. Instead of just neutralizing stomach acid like some antacids, omeprazole can suppress acid production altogether. It comes from a class of drugs called proton pump inhibitors (PPIs). These drugs directly affect the parietal cells in the stomach that produce hydrochloric acid (i.e. stomach acid).

Normally, the parietal cells exchange protons (i.e. hydrogen ions or H+) for potassium ions (K+) through a proton pump. An enzyme called hydrogen/potassium ATPase (or H+/K+ ATPase) facilitates this exchange, and the end result is hydrochloric acid production.

After a dog takes omeprazole, it enters the bloodstream then diffuses into the stomach’s parietal cells. Next, it accumulates in a little fold in the cell and becomes activated. Finally, the active form (tetracyclic sulfenamide) irreversibly binds to H+/K+ ATPase, inhibiting the proton pump.

Because this binding cannot be undone, the parietal cell must make more proton pumps to be able to keep making stomach acid. This takes time, so omeprazole administration results in prolonged gastric acid suppression. 

Adult dog lying down on bed
Omeprazole is primarily used to treat ulcers in the stomach and small intestines.

What is omeprazole used for in dogs?

This reduction in acid production is helpful for several conditions in veterinary medicine:

Stomach and intestinal ulcers

Veterinarians will primarily prescribe omeprazole to treat ulcers in the stomach and small intestines. Sometimes they will also use the combination of omeprazole and sucralfate for dogs with ulcers. Sucralfate is a great short-term addition because it acts like a band-aid to help protect and heal the ulcerated areas. And the omeprazole decreases acid production to help prevent further ulceration.

Omeprazole can also be a great choice for dogs who are prone to stomach ulcers. For example, dogs who take certain medications like non-steroidal anti-inflammatory drugs (NSAIDs) may be more likely to form ulcers.

This is because NSAIDs can inhibit the lipid molecules called prostaglandins that form the mucus barrier that lines the stomach. When this protective barrier is lessened, the stomach acid can eat away at the inside of the stomach. Also, NSAIDs themselves can be slightly irritating to this protective lining. The combination of these two effects leads to erosion or ulceration in the stomach wall.

Sometimes dogs on steroids such as prednisone for dogs may also be at a higher risk of stomach ulcers. For this reason, the vet may decide to use omeprazole and prednisone for dogs in certain situations.

Acid reflux or esophagitis

Omeprazole can also be useful for patients who have acid reflux in dogs or esophagitis (i.e. inflammation of the esophagus). The esophagus (i.e. the tube that connects the mouth to the stomach) can be susceptible to erosions and ulcers. This is especially the case when the valve between the esophagus and stomach (called the cardiac sphincter) leaks stomach acid up into the esophagus. Suppressing acid secretion in the stomach will help prevent further irritation to the esophagus.

Helicobacter spp. treatment

Even though the stomach is a very acidic environment, some bacteria can flourish in these conditions. One such bacteria is Helicobacter spp.. Infected dogs may be asymptomatic, but they could also experience symptoms such as vomiting and inappetence. This bacteria can cause inflammation of the lining of the stomach (i.e. gastritis) too.

By giving omeprazole, the inside of the stomach becomes less habitable for Helicobacter. This makes antibiotics more effective.

Gastritis

Omeprazole may also be helpful for cases of gastritis that are related to other factors such as:

  • Exercise— Exercise-induced gastritis has been described in sled dogs and dogs who race professionally.
  • Stress— For dogs with chronic stress, the protective mucosal layer inside the stomach becomes compromised.
  • Tumors—If the dog has an acid-producing stomach tumor (i.e. gastrinoma), the excess acid can also lead to gastritis.
Dog lying outside in the grass
Stress, exercise and tumors may cause increased acid in your dog’s stomach.

Omeprazole for hydrocephalus in dogs

Interestingly enough, omeprazole may also decrease the production of cerebrospinal fluid (CSF). This can be helpful as an adjunctive treatment for hydrocephalus in dogs (i.e. an abnormal build up of CSF in the brain). It may also be useful for dogs with syringohydromyelia, a condition where abnormal CSF-filled cavities develop in the spinal cord.

How long will omeprazole take to work?

When your dog is experiencing tummy troubles, you understandably want him or her to feel better as soon as possible. For some dogs, it might only take 24 to 48 hours to get some relief from gastritis or esophagitis. However, it can take two to four consecutive days of omeprazole usage to see maximal effects. This is because it takes a few days to inhibit enough proton pumps to see a big difference.

When aiming for maximal efficacy, it is also important to know that omeprazole always works better on an empty stomach. Ideally, you would give the omeprazole to your dog about one hour prior to breakfast. The reason for this is that the longer the fast (such as overnight), the more H+/K+ ATPase that is present in parietal cells. This means more targets for the omeprazole to inhibit, which in turn means better reduction of acid production.

What is the omeprazole dose for dogs?

As you can imagine, it is also important to give your dog the right amount of omeprazole. Typically, veterinarians will calculate the dose for omeprazole (in milligrams or mg) based on the dog’s bodyweight (in kilograms or kg). This is accomplished by multiplying the omeprazole dose (in mg/kg) by the dog’s weight (in kg).

Different conditions may require a different dose of omeprazole. So it is always best to consult your veterinarian to find the dose that is right for your dog.

Your vet will also advise you on the best dosing frequency. Usually, he or she will recommend giving your dog omeprazole every 24 hours on an empty stomach for five to seven days to start out. Administering it an hour before breakfast is ideal. If your dog isn’t doing well at that dose, your vet may recommend switching to twice daily dosing (i.e. every 12 hours).

Dog mom holding a small white dog in her hands and looking at her cell phone as if searching for info about omeprazole for dogs
If you feel your dog would benefit from omeprazole, please contact and discuss with your Vet.

What dosage forms does omeprazole come in?

Additionally, the vet will often suggest the form of omeprazole that would work best for your dog. Omeprazole labeled for humans comes in capsules, tablets, and a liquid formulation. These tend to be the options that vets pick for dogs as well. The most commonly available dosage form is the over-the-counter omeprazole 20 mg tablet or caplet, which is given orally. However, omeprazole is also available in 10 mg and 40 mg sizes. For tiny dogs, there is also the option of an omeprazole liquid.

There are granule formulations and oral pastes available but these are made for horses specifically so they have a higher concentration of omeprazole. This makes sense since horses weigh so much more than dogs. However, it also makes these dosage forms fairly impractical to use for most dogs.

Unfortunately, there is no injectable form of omeprazole. However, a cousin of omeprazole called pantoprazole is available in an intravenous formula. This is useful for patients in a hospital setting.

A word of warning: Although you can buy omeprazole over-the-counter, it is always best to talk to your vet before giving it to your dog. Omeprazole isn’t right for every dog or every situation and it is important to give your dog the correct dose for best efficacy.

What are the omeprazole side effects in dogs?

In addition to knowing how much omeprazole to give your dog and how often, it is also important to know about any side effect to watch for. Luckily, omeprazole is safe for dogs and adverse effects are very rare. Some dogs who take omeprazole may experience the following side effects:

  • Vomiting
  • Diarrhea
  • Gas and mild bloating
  • Decreased appetite

If your dog does exhibit side effects, they should be short-lived. In most dogs, omeprazole stops working about 24 hours after the last dose. However, the effects may linger for a little longer if the dog has liver disease in dogs or kidney failure in dogs. This is because the kidneys and liver are responsible for removing omeprazole from the body.

Thankfully, the safe dosing range is quite wide, and overdosing is extremely rare. In fact, the long-term use of very high doses of omeprazole has been studied in dogs over a period of seven years with no adverse effects.

This study is important because recent lab animal studies suggest that longer term omeprazole use in humans may increase the risk of certain stomach cancers. Understandably, this raised concerns among vets about the long-term use of omeprazole in dogs. However, the 7-year study mentioned previously did not show any evidence of stomach cancer development in any of the study dogs.

It is worth remembering though that long-term acid suppression might make it easier for certain bacteria to invade the stomach. If the dog vomits, then aspirates stomach contents, this could lead to a severe lung infection.

Are there dogs who should not take omeprazole?

We have just established that overall omeprazole is well tolerated by most dogs. But that doesn’t mean that it is right for every dog. Dogs who are sensitive to the effects of omeprazole or medications like it (e.g., pantoprazole) should not take omeprazole or any other proton pump inhibitor.

Also, dogs with liver disease or kidney disease should take very low doses of omeprazole. Safety has not been evaluated in pregnant or lactating dogs, so it is best to avoid giving it to them too.

Dog looking sad lying on the carpet
Not all dogs can take omeprazole, discuss your pets current medications with your Vet.

For dogs taking certain medications, concurrent use of omeprazole may decrease medication absorption or increase the amount of medication present in the body. Before giving omeprazole to your dog, be sure to ask your vet about possible drug interactions. This is primarily a concern if your pup is taking any of the following:

  • Benzodiazepines (like diazepam or alprazolam)
  • Clarithromycin
  • Clopidogrel
  • Cyclosporine
  • Digoxin
  • Ketoconazole
  • Levothyroxine
  • Phenytoin
  • Rifampin
  • Warfarin

In the same way, if your pup takes any supplements, senior dog supplements, or vitamins (especially B vitamins), omeprazole may decrease their absorption.

What are some alternatives to omeprazole for dogs?

As you can see, there may be times when a dog can’t take omeprazole due to the above contraindications. Or maybe your large or giant breed’s omeprazole is getting a bit pricey so you are looking for other options. The good news is that there are some alternative antacids and other therapies that can help dogs who have or are prone to ulcers, vomiting, or other GI issues. However, as always, your vet is the best person to decide which, if any, of these options is best.

Omeprazole vs famotidine for dogs

Famotidine (which is sold under the brand name Pepcid®) is another popular antacid. It falls into a slightly different category than omeprazole. You see, besides harboring proton pumps, parietal cells also have histamine receptors. These receptors bind histamine (H2) and are utilized in the production of stomach acid. H2-receptor antagonists (i.e. blockers) like famotidine can reversibly bind to these receptors, effectively keeping them from producing acid.

In short, omeprazole and famotidine work to create the same effect—blocking acid production. However, omeprazole tends to be the more effective antacid because it has longer-lasting effects. Omeprazole can be given every 24 hours while famotidine is typically repeated every 12 hours in dogs.

Antacids to avoid

There are some antacids you are better off skipping, though. Other popular antacids such as Tums (calcium carbonate) and Pepto Bismol (bismuth subsalicylate) can be problematic.

Some Tums formulations contain an artificial sugar known as xylitol for sweetening and flavoring. Xylitol can be deadly for dogs due to sharp drops in blood sugar, and it can last in their bodies for a few days.

And Pepto Bismol for dogs isn’t a great idea either. It can turn your dog’s stool a scary black color, and the subsalicylate ingredient may worsen GI upset or occasionally lead to ulcers.

Options other than antacids

Even though there are relatively safe antacids like omeprazole and famotidine, you should still consult your vet before giving them to your dog. While waiting to hear back from your vet, there are a few things you can do to help your dog’s stomach upset.

Bland diet

If your dog is vomiting, skip giving any more food or treats in case more vomiting is to come. The more vomiting that occurs, the more irritated the esophagus will become. If several hours go by and there hasn’t been any more vomiting, it may be safe to give a small amount of a bland diet for dogs. A little cooked rice and cooked chicken is a great option because these food items are bland yet easy to digest. However, remember to avoid any oils or seasonings when preparing the chicken and rice.

Probiotics

Another option is trying one of the many probiotic supplements available over the counter for dogs. Probiotics are live cultures of bacteria. They promote a healthy digestive tract, primarily because they compete with harmful bacteria for space in your dog’s intestines.

Probiotics for dogs may come in a powdered or tablet form. However, unlike for people, probiotic yogurt isn’t a great idea for dogs. Most dogs are intolerant to the sugars (lactose) found in dairy products, which means yogurt may make GI distress worse.

Other home remedies

Most people have their favorite home remedies for stomach upset, some of which might be safe and helpful for dogs. Unfortunately, there are few studies to prove their efficacy. But anecdotal evidence suggests that ginger root products for dogs may help settle an upset tummy. There are also anecdotes implying that giving a few slices of banana might soothe a sour stomach.

Ask your vet about omeprazole for dogs

As you have learned, omeprazole has some great benefits for dogs. It is useful for stomach ulcers, acid reflux, gastritis or other GI issues. Plus, it may only need to be given once a day, is safe for dogs, and effectively suppresses stomach acid secretion.

If your dog is having some tummy troubles and you are wondering if omeprazole would be a good idea, give your vet a call. He or she can examine your dog, give you an idea of what is wrong, and then create a treatment plan. Perhaps omeprazole might be just what your dog needs to get back to feeling great again.

Has your dog taken Omeprazole?

Please share your experiences in the comments.

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Filed Under: Common Dog Health Problems, Our Blog: The Buzby Bark

Reader Interactions

Comments

  1. Joanna says

    November 9, 2023 at 2:24 pm

    My dog has been prescribed Omeprazole we are on day 3 and still have a little bit of vomiting each day.

    Reply
    • Dr. Julie Buzby says

      November 16, 2023 at 1:01 pm

      Hi Joanna,
      I’m sorry to hear that your pup is still vomiting. It would be a good idea to check in with your vet at this point if you haven’t already. I don’t know what condition your vet prescribed the omeprazole for, but continued vomiting could mean that your dog’s condition is worsening or your dog needs further diagnostics to get to the bottom of what is going on.
      I hope you are able to find some answers for your dog so that he or she can start feeling better soon!

      Reply
  2. John says

    August 23, 2023 at 5:43 pm

    Our Westie was prescribed 10mg Omezaprazole and 24mg Cerenia tablets and it worked very well.
    We think she had eaten something she shouldn’t have and had a very upset stomach, with associated loss of appetite and bile sickness for days.
    A bland chicken and rice diet (very little and often) together with this prescription worked very well and she is now completely back to her wonderful mischievous self again.

    Reply
    • Julie Buzby DVM says

      August 23, 2023 at 6:14 pm

      Hi John,
      This is such great news! Thank you for sharing your success story with our readers. Best wishes to you and your Westie.

      Reply
  3. Mary says

    August 4, 2023 at 2:23 am

    I started my preemie 2 month old puppy on this medication, prescribed from the vet. Since I gave it to her, she had been extremely tired, has diarrhea, and not eating as well. Is this normal?

    Reply
    • Julie Buzby DVM says

      August 5, 2023 at 5:20 pm

      Hi Mary,
      I would not expect Omeprazole to cause these symptoms. While any medication can cause some upset stomach, this one should help to prevent it. I am suspicious there is more going on that could be contributing to your puppy’s problems. Please reach out to your vet and let them know about these new issues.

      Reply
      • Amy says

        August 18, 2023 at 9:42 pm

        Your contradicting yourself. Your article states side affects can be diarrhoea and decreased appetite.

        Reply
        • Julie Buzby DVM says

          August 22, 2023 at 2:44 pm

          Hi Amy,
          I understand how my previous comment could be confusing. I will try to clarify. Diarrhea and upset stomach are the main side effects for just about every drug/medication. Since the previous reader was specifically asking about a small puppy, I am always on high alert for any decrease in appetite and diarrhea as these symptoms can be early signs of the deadly Parvo virus. So, while Omeprazole could be playing a role in her dog’s worrisome symptoms, I am suspicious more could be going on here and think it would be wise to seek veterinary care/advice. I hope that makes sense? Thank you for calling this to my attention. Best wishes!

          Reply
    • Nancy Gordon says

      November 4, 2023 at 7:24 am

      I have a basset rescue with major stomach issues. Tried the antacids.. prilosec made him very lethargic and he didn’t want to eat. it was absolutely the Prilosec, because when we stopped, he started eating again. We’ve moved on to his own diagnosed motility issue however, he still has issues. Hopefully we can figure this out soon.

      Reply
      • Julie Buzby DVM says

        November 6, 2023 at 8:58 am

        Hi Nancy,
        Sorry your Basset has had so many issues with his medications. Hoping you can get some answers quickly and ensure your sweet boy is happy and healthy. Wishing you both the best.

        Reply
  4. Gorman Tee says

    July 6, 2023 at 4:32 pm

    Just wanted to say THANK YOU for a great article! Knowledge is power and you just shared a ton of it. Greatly appreciated.

    Reply
    • Julie Buzby DVM says

      July 7, 2023 at 10:54 am

      Hi Gorman,
      Thank you for the great feedback! Glad the article was helpful and informative. Best wishes!

      Reply
  5. Susan Headrick says

    June 25, 2023 at 4:00 pm

    My 6 year old lab has gastrointestinal problems she’s been put on Omprezole and Rimadyl. . I don’t give her much of the Rimadyl anymore it concerns me. The other one I give every morning to her and her feces is still not solid like it use to be. I slowly changed her dog food to Hills digestive food kibbles for a week but she still licks her lips and chews some grass. I’m wondering what to do from here.

    Reply
    • Julie Buzby DVM says

      August 30, 2023 at 10:42 am

      Hi Susan,
      While Omeprazole is great for decreasing stomach acid and helping to heal ulcers, it doesn’t treat all sources of nausea. You mentioned your Lab is licking her lips and eating grass which can be symptoms of nausea. I recommend you talk to your vet and see if they could prescribe something in addition to the Omeprazole. There are also great options for probiotics that could help with the loose feces. Hoping this helps direct your conversations with your vet. Wishing you both the best!

      Reply
  6. Renee says

    June 13, 2023 at 5:27 pm

    My 50 pound Husky has a liver shunt and is taking Omeprazole 20mg 2 times a day. Is this too much? She is limping all the time and her belly turns pink a couple of hours after taking the med.

    Reply
    • Julie Buzby DVM says

      June 13, 2023 at 9:36 pm

      Hi Renee,
      I understand your concern with these strange symptoms you are noticing in your Husky. Since I haven’t personally examined your dog, I can’t make specific conclusions or recommendations on medication dosages. Please make sure your vet is aware of what is happening. They may decide to do some investigation or try a different treatment all together. Hoping you get answers quickly and wishing you the best of luck.

      Reply
  7. Linda Richter says

    May 2, 2023 at 8:39 am

    my Lhasa has been on pepsid. starting Omeprazole today. Have some kidney issues also. But has so much lick lipping and regurgitating, doesn’t want any food. so hoping this helps.

    Reply
    • Julie Buzby DVM says

      May 9, 2023 at 10:34 am

      Hi Linda,
      I too am hoping the omeprazole will do the trick. Praying your pup is feeling better soon. ♥

      Reply
  8. Leba Miller says

    April 22, 2023 at 7:52 pm

    My Jack Russell is almost 16 and has GERD.. I was going to give her famotidine until I read your article. She’s 20lbs and I’m wondering how much to give her.

    Reply
    • Julie Buzby DVM says

      April 23, 2023 at 2:46 pm

      Hi Leba,
      Without playing a personal role in your dog’s veterinary care, I can’t give you specific medication dosages. I recommend you talk to your vet about the possibility of starting omeprazole. If they decide it would be beneficial for your dog’s condition, they will give you the dose that is best for your pup.

      Reply
  9. Char Ball says

    April 13, 2023 at 10:11 pm

    my 12 yr old Catahoula, 80 lbs has been on omprazole 20mg once a day before breakfast.for a year by instruction of our Vet. Our Dr. quit leaving us with the other Dr. in the office.
    That Dr. didn’t like that Our dog had been on it for a year without a break and told us to stop and give it a rest.
    After 5 days he has lost his appetite and has has a few small vomit areas .
    Not sure what I should do next leave him off and have him miserable or do what the original Dr. said to do and give him peace.
    will my dog have get better the long he is off it?
    thanks I value you opinion
    Char

    Reply
    • Julie Buzby DVM says

      May 15, 2023 at 10:29 am

      Hi Char,
      I am sorry you are in this difficult situation with your senior guy. Without being personally involved in his medical care, I can’t make specific recommendations. It does seem like the omeprazole may be needed since your dog was doing well while taking it and then the issues started once stopping the medication. Have you discussed these issues with the other doctor? Don’t forget, it is always ok to seek a second opinion if you have lingering questions or concerns. I am hopeful you will find the best way to keep your sweet boy happy and healthy. He is lucky to have someone like you advocating for his well-being!

      Reply
  10. Kris vintinner says

    April 12, 2023 at 10:10 pm

    Great information! I didn’t see signs symptoms for use in your dog? I have a 108lb boxer 7yr old occasionally I’d say usually always at night does this nervous behavior gulping swallowing licking with some belching and is very very needy needs you constantly patting him. He use to have one meal a day at some time between 5-6:00 chicken rice and vegetable and some treats during the day. Yes we cook their food we have 3 boxers! But we recently started breaking that meal into 2 in the morning to help with indigestion and giving probiotics. And now we think he’s got acid reflux and/or ulcer so we’re gonna start the omeprazole and see how he does. I think this is definately the answer if not we will go back the vet. But I was wondering the indications for usage or symptoms for omeprazole? Thank you.

    Reply
    • Julie Buzby DVM says

      April 23, 2023 at 6:43 pm

      Hi Kris,
      It does sound like your pup may be experiencing some issues with his stomach. I recommend you talk to your vet and make sure they don’t want to do some investigation prior to starting your boy on omeprazole. I would hate to assume he is dealing with reflux and miss a more serious issue that could be easily resolved if caught early enough. At the title indicates, omeprazole is an antacid. So the indications for usage are for any condition or disease that involves increased acid production in the stomach. There are too many possible symptoms to consider, this is why it is important to partner with your vet to get a diagnosis first. I am hopeful you will find the best way to maintain your sweet boy’s health. Wising you and yours the best!

      Reply
  11. Mary Murkar says

    April 7, 2023 at 2:55 am

    My little dog has been prescribed Omeprazole liquid, and takes it once a day, along with Famotodine. It, is a compound liquid, that I have filled and delivered through a mail order pharmacy. The medication itself, is very reasonable, but the refrigerated shipping, adds an extra $45 to the order, on a monthly basis. Is there any alternative? He’s doing so well, that I hate to change, but $70 monthly, is a lot for me. How can I find a local veterinary pharmacy, that deals with compound medications?

    Reply
    • Julie Buzby DVM says

      April 18, 2023 at 1:59 pm

      Hi Mary,
      I am sorry you are having such a tough time with the cost of your pup’s medication. There is probably not a local veterinary pharmacy, but ANY compounding pharmacy may be able to make this medication for you. I have a human compounding pharmacy in my area that I can call to fill prescriptions for my veterinary patients. As long as the drug you are wanting compounded is not exclusively used in veterinary medicine, a human pharmacy may be able to help. Luckily omeprazole is used in human medicine as well. Please make sure your vet is aware of this financial strain. They may already have a plan B and just haven’t mentioned it because they didn’t realize there were concerns with plan A (if that makes sense?). I am hopeful you can find a better solution that will make things easier to bear. Wishing you the best of luck!

      Reply
  12. Susie says

    March 6, 2023 at 7:20 pm

    Hi there, if found to be acid reflux, is Omeprazole a drug that can be taken long term for a dog? Also, is it a drug that just “works on the day” (eg the human equivalent of gaviscon or tums, simply settling it on the day) or, is it a drug that has to have a few days build up to work? Many thanks.

    Reply
    • Julie Buzby DVM says

      March 7, 2023 at 8:44 am

      Hi Susie,
      Yes, Omeprazole can be used in dogs on a long-term basis. But make sure to check with your veterinarian before administering any type of medication to make sure your dog doesn’t have any issues that would make this treatment a poor choice. You wouldn’t want to unintentionally cause harm to your pup. And the information you are looking for as to how Omeprazole works can be found in the article under the paragraphs titled “How does it work?” and “How long will omeprazole take to work?”. I hope that helps a bit. Take care!

      Reply
  13. Laurie L. says

    January 31, 2023 at 12:36 pm

    My 2 year old aussie has been on omeprazole, as originally advised by our vet, for vomiting. She is also eating Hill’s Prescription Diet i/d Stress and Calming Care probiotic. It’s now been a couple months that she’s been on omeprazole. It seems any time I forget to give it to her, she vomits. Will this be a medication she will need for the rest of her life?

    Reply
    • Julie Buzby DVM says

      February 13, 2023 at 10:59 am

      Hi Laurie,
      I am sorry your Aussie is having so many GI issues. I understand your concern with her persistent vomiting when the omeprazole is not given. She may indeed have to stay on some type of antacid long term. Make sure your vet is aware of these ongoing symptoms. They may decide to do some more investigation. The next steps could include a referral to a specialist or the need to scope your dog’s upper GI tract. I am hopeful you will find the answers you need to help restore your girl’s health and quality of life. Wishing you both the best.

      Reply
  14. Frances says

    January 27, 2023 at 7:23 am

    My Bonnie, a 17 yo chi hua hua, used to be a very healthy dog. She has no health issues at all until mid of June 2022. During her annual medi check in June, the vet done a stomach ultrasound on her and found out her stomach lining was thickening. The vet suspects it is due to gastritis or an ulcer inside her stomach. So she suggested us to use omeprazole tablets to see if that helps. The first day after I gave the omeprazole to my dog, she was having diarrhea for hours. On the second day, she started vomiting shortly after taking the medicine and it became progressively worse. She kept vomiting from evening until 6++ a.m. the next morning. You can even see the BLOOD in her vomit. I stopped the medicine immediately and went to the vet. Vet done a blood and urinalysis test on her and report came back was good. 2 days later, blood was found in her urine. We went to vet again, do some testing on her urine. Report shows USG reading was good and vet concluded that she was having urinary track infections. I went to 2 different vet after that and did 3 urinalysis test in total, the reports were all good and both vets also said it was a common UTI due to her age. But 2 weeks later, she was diagnosed with stage 4 kidney failure. So, I just want to know, is this omeprazole tablet causing kidney failure in my dog? Thanks

    Reply
    • Julie Buzby DVM says

      February 11, 2023 at 1:05 pm

      Hi Frances,
      I am sorry Bonnie has dealt with so many issues this past year. Unfortunately, without examining your dog myself and being involved with all the case details, there is really no way for me to make specific conclusions. Bonnie’s case sounds a bit complicated. With so much happening in such a short period of time, it is almost impossible to know if the omeprazole played a role in her kidney dysfunction or not. I would not think this is the case since the lab work performed just after the diarrhea and vomiting started showed no abnormalities. Also, I am a bit curious to know why the stomach ultrasound was recommended in the first place as this is not typically part of a routine yearly physical for dogs. With that being said, I hope Bonnie is maintaining well and still able to live a happy life. Wishing you all the best.

      Reply
  15. Ruth A Verdolin says

    January 21, 2023 at 8:11 am

    My dog W is almost 15 years old. Over the years she had acidiy and we resolved with omeprazole. Now, she is taking Galliprant for mobility and pain. After a month of 1 galliprant a day she is developing dark stool and very soft. Can I combine 1 Galliprant with omeprazole?
    Thanks,
    R

    Reply
    • Julie Buzby DVM says

      January 31, 2023 at 1:52 pm

      Hi Ruth,
      I understand your concern for your senior girl and these changes to her bowel movements. I think it would be best to have her examined by your vet prior to adding in the Omeprazole. Depending on how “dark” the stool is this could be a sign of more serious issues. Your vet will probably want to get a fecal sample and do some testing to rule out some of the possible causes. How are things today? Hoping everything has resolved and your pup is back to normal.

      Reply
  16. Tim Clark says

    November 18, 2022 at 2:24 pm

    my jack Russell seems to be swallowing and slurping at night I wondered if it could be reflux as on occasions quite rarely he will vomit bile in the morning but quite rarely,many thanks

    Reply
    • Julie Buzby DVM says

      November 20, 2022 at 6:06 pm

      Hi Tim,
      What you are describing could be signs of reflux in your pup. I recommend you discuss these concerns with your vet and see if they want to try a course of medication. Good luck!

      Reply
  17. Fr jim says

    July 29, 2022 at 4:28 pm

    Two of my three Chocolate labs (aka garbage can eaters) were on (vet recommended) famotidine…. 2xdaily…

    I’ve begun to give the latest one to rescue me, probiotics with homemade Greek yogurt…
    So far, so good!

    Reply
    • Julie Buzby DVM says

      August 1, 2022 at 3:14 pm

      Hi Fr jim,
      Famotidine is great and I prescribe it all the time. I am glad you found something that works for your Labs. Keep up the good work!

      Reply

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