Finding out your senior dog’s blood work showed a high ALP can be confusing and concerning. Thankfully, integrative veterinarian Dr. Julie Buzby is here to help you make sense of high ALP in dogs. She explains what it is, why it can sometimes be elevated, and what the next steps might be.
Sampson, a 12-year-old Jack Russell Terrier mix with a zest for chewing sticks and chasing squirrels, was in to visit me recently. During a particularly vigorous stick chewing session he had cracked a tooth. As a result, he needed a dental procedure under anesthesia to remove the damaged tooth and clean the rest of his teeth.
I always recommend some basic bloodwork prior to any of my older doggy patients going under general anesthesia. Pre-anesthetic lab work helps ensure a dog isn’t at an increased risk for complications with anesthesia or the specific procedure. It also has the added benefit of occasionally picking up on medical issues before they become a bigger problem. That was how we found that Sampson’s ALP, while normal on his last yearly bloodwork, was now moderately high.
Sampson’s dog mom, Sarah, was the proactive type and had many questions about ALP. I answered her questions in detail before we formulated a plan.
What is ALP in dogs?
The abbreviation “ALP” stands for alkaline phosphatase, which is an enzyme many routine blood panels may measure. Primarily, the liver produces ALP, though there are other sources too. We will come back to this later in the article because it is important.
Within the liver, ALP is found along the outer layer of the liver cells. Even more specifically, it is associated with the liver cells that line the bile ducts. Alkaline Phosphatase’s normal job in the body is complicated, and actually isn’t critical to understand here. But what is important to understand about ALP is that it is a sensitive indicator of liver or gallbladder dysfunction.
A brief physiology lesson
The liver is an amazing organ that has, by many estimates, over 500 critical jobs in the body. To name a few, the liver is responsible for:
- Removing toxins from the bloodstream
- Regulating blood sugar (along with the pancreas)
- Taking old red blood cells out of circulation
- Releasing clotting factors
The liver is also responsible for making bile, which flows through ducts in the liver to the gallbladder. Bile is then released from the gallbladder into the GI tract where it helps with digestion.
With all these important functions, it would only make sense that keeping tabs on your dog’s liver is an important part of keeping him or her healthy. This is where ALP liver enzymes (among other liver enzymes) comes in.
How would the vet detect high ALP levels in dogs?
When your veterinarian performs general wellness blood work on your dog, either as part of a yearly exam or as part of a pre-anesthetic check-up, chances are the blood work will include a chemistry panel. This test measures protein and electrolyte levels. It also includes values that can offer clues about the function of the liver, kidneys, and pancreas.
For a chemistry panel, the vet or vet nurse will draw a small amount of blood from your dog and place in a test tube. Then, your veterinarian may sometimes perform the blood tests with an in-house laboratory machine. Alternatively, he or she can send your dog’s blood to an outside veterinary diagnostic lab. If your veterinarian runs these tests in-house, your results may be ready the same day. But if your vet sends the blood out, it can take several days for the final results to be available.
Liver values
The markers related to the liver on a chemistry panel include ALP, ALT, GGT, and total bilirubin. The liver also makes glucose, cholesterol, albumin, and BUN. These levels can give clues to how well the liver is functioning.
ALT, or alanine transferase, is what is known as a “hepatocellular” liver enzyme. When the cells of the liver are damaged, this enzyme leaks out into the blood. Elevated ALT is often more worrisome than high ALP to veterinarians since it indicates ongoing damage to the liver cells.
ALP and GGT are what are known as “cholestatic” enzymes. This means that elevations predominantly occur if there are issues with the flow of bile, either within the liver, or as it leaves the gallbladder.
Forms of ALP
Earlier we touched on the fact that the liver makes alkaline phosphatase (ALP), but other places in the body make it too. The three most important forms are ALP from the liver (L-ALP), ALP made in the bone (B-ALP), and ALP that is released in response to excess levels of corticosteroids (C-ALP). A chemistry panel measures all three of these forms together as ALP. Therefore, based on the chemistry panel alone, it is not possible to determine which form is contributing most to an elevated ALP.
Liver ALP
As the name implies, L-ALP elevations are often related to issues with the liver. This is the focus of much of the rest of the article.
Bone ALP
Increased ALP activity is common in young dogs who are growing rapidly because normal bone growth releases B-ALP. Generally, these dogs are less than a year old. In a young dog, a mild elevation in ALP is not a worrisome finding if the remainder of the liver values are normal and the dog is otherwise feeling well. However, conditions that cause ongoing damage to the bones, such as bone cancer (i.e. osteosarcoma) or infections within the bone (i.e. osteomyelitis), can also cause elevations in B-ALP levels.
Corticosteroid ALP
The liver produces corticosteroid-induced ALP in response to elevated blood steroid levels. These high C-ALP levels can either be due to the body producing increased amounts of steroids, as with Cushing’s Disease in dogs, or they can be from oral or topical steroid-containing medications.
What causes high ALP in dogs?
Many times, a vet will find high ALP in senior dogs. In fact, it is one of the most common lab work abnormalities in older dogs. An elevated ALP is very sensitive in its ability to assess for hepatobiliary disease (i.e. diseases affecting the liver, gallbladder, or bile ducts) in dogs and cats.
This means that most dogs with significant liver disease will have an elevated ALP. That sounds like great news, right? If that’s the case, an ALP blood test should be the perfect way to help decide if your dog has liver disease.
Unfortunately, it is not quite that simple. While a high alkaline phosphatase level is very sensitive, it is not also a non-specific finding. This means that lots of other conditions aside from liver disease can cause an elevation in ALP. The list of conditions that can cause an elevated ALP includes:
Liver or gallbladder conditions
Any disease that causes a back-up of the flow of bile (i.e. cholestasis) will cause increased serum ALP levels in dogs. Cholestasis can be due to primary liver disease in dogs. Structural problems that block the flow of bile out of the liver, into the gallbladder, or from the gallbladder into the intestinal tract, can also cause a high ALP in dogs. Finally, secondary liver diseases (i.e. other conditions that cause ongoing damage to the liver) also will cause an elevated ALP level.
Primary liver diseases include:
- Infectious hepatitis due to ascending bacterial infections, Leptospirosis (lepto in dogs), etc.
- Chronic active hepatitis
- Copper storage disease
- Benign nodular hyperplasia
- Vacuolar hepatopathy in dogs
- Hepatocellular carcinoma (i.e. a type of liver cancer)
Gallbladder diseases include:
- Cholelithiasis (i.e. gallstones)
- Cholecystitis (i.e. gallbladder infection)
- Gallbladder mucocele in dogs
- Bile duct carcinoma (i.e. cancer of bile ducts)
Other medical conditions
Many medical conditions that are unrelated to the liver itself can also cause a high ALP. They range from non-worrisome to very concerning. Some of these include:
Endocrine diseases:
- Diabetes mellitus
- Hypothyroidism in dogs
- Cushing’s disease
- Hyperparathyroidism
Non-liver cancers:
- Lymphoma in dogs
- Pancreatic carcinoma
- Osteosarcoma (i.e. bone cancer)
Other diseases:
- Pancreatitis in dogs
- Gastroenteritis (I.e. inflammation of the stomach and intestines from various causes)
- Osteomyelitis (i.e. bone infection)
Toxins
Any toxins that cause substantial liver damage can also cause a high ALP in dogs. However, these elevations will not normally be as significant as the increases in ALT levels. Some toxins that cause liver damage are:
- Xylitol toxicity in dogs
- Cycad palms (i.e. sago palms)
- Zinc
- Aflatoxin
- Amanita mushrooms
- Blue Green algae toxicity in dogs
Breed-related elevations
Certain dog breeds can have increased ALP levels without it being a problem. The most common breed-related cause of increased ALP is Benign Familial Hyperphosphatasemia in Siberian Huskies. Scottish Terriers can also have a similar condition.
Medications
Some medications also are connected with elevated ALP in dogs. Two of the most common are:
Phenobarbital
This is a common medication vets use to treat dog seizures that can benignly increase L-ALP levels. However, phenobarbital can also occasionally cause damage to the liver. This means that if a dog taking phenobarbital has a high ALP, it can be hard to determine if the ALP elevation is no big deal, or if it might indicate a bad reaction to this medication.
If you find your dear dog in this situation, your veterinarian will likely start by evaluating how your dog is feeling. He or she will also look at the levels of the other liver values on the chemistry panel. In cases where the ALP elevation is severe, your dog is feeling poorly, or your dog has other liver enzyme elevations, then your veterinarian may recommend additional liver function testing.
In some cases, dogs will need to stop phenobarbital due to concerns about liver damage. The good news is that in most dogs, the liver values quickly go back to normal when the vet weans them off phenobarbital and onto one of the other medications available to help control seizures.
Steroids
Oral steroids, like prednisone for dogs, commonly cause moderate to severe elevations in ALP. Higher doses of steroids, such as those used for immunosuppression in cases of IMHA in dogs or other immune-mediated conditions, tend to cause higher ALP elevations.
Luckily, the increase in ALP from steroids does not generally correlate with long-term liver damage or liver dysfunction. However, it is important to know that once the dog stops taking steroids, it can take much longer—up to several months—for the ALP levels to normalize.
If your dog has an elevated ALP level, ensure you tell your veterinarian about all the medications your dog is taking or has recently taken. Some eye and ear medications and skin sprays or ointments contain steroids. Even these topical steroids can lead to ALP elevations during or after treatment.
Is a higher ALP automatically worse for dogs?
You may be wondering if you can use the degree of ALP elevation to tell you how bad the underlying problem might be. It would be easy to think that if a dog has a very severely elevated ALP, her or she might have a worse prognosis. Happily, this is not always the case.
Some benign and completely reversible issues, like taking high doses of steroids, can cause very severe elevations in ALP. However, if there is not an obvious reason for the high ALP (like taking a course of steroids), then your veterinarian may use the degree of elevation to help decide how aggressive to be with additional diagnostic testing.
What are the next steps for a dog with a high ALP?
If your dog has a high ALP, your veterinarian will start with a detailed medical history and thorough physical examination. In many cases, clues from the exam and history can help point your veterinarian to the next best diagnostic test to perform.
Every case is different, but the most common and least invasive next step is often to perform full lab work. This typically includes a CBC (i.e. complete blood count), full chemistry panel (if the ALP elevation was found on a “short” panel), T4 level, and urinalysis. If the remainder of your dog’s lab work is normal, he or she is otherwise feeling well, and the physical exam reveals no major concerning changes, then your veterinarian may elect for the “watchful waiting” approach.
With this approach, your veterinarian would hold off on performing any additional diagnostic testing right now. He or she will repeat lab work periodically to monitor trends in the ALP and other liver values. If the ALP improves or remains mildly elevated, then together you may elect for continued “watchful waiting.” If the ALP elevation gets worse, repeat bloodwork shows other abnormalities, or your dog develops any new medical symptoms, then your veterinarian will likely recommend additional diagnostic testing.
Liver function testing
One additional non-invasive lab test that your veterinarian might recommend is a liver function test which measures bile acid levels. Bile acids are made in the liver, stored in the gallbladder, and released into the intestines to help digest fat after you, or your dog, eats a meal. If the liver is working well, these bile acids are pulled back out of the bloodstream to be recycled and used again. However, if the liver is not functioning well, it is unable to remove the bile acids from the bloodstream and the bile acid levels will be high.
Your veterinarian can measure bile acid levels by taking two blood samples and sending them to an outside veterinary diagnostic lab. Your dog must have fasted for 12 hours prior to the first blood draw. Then your veterinarian will feed your dog a small snack, which should cause the gallbladder to release bile acids. Next, the vet will take another blood sample two hours later to see if the liver was able to remove the released bile acids from the bloodstream.
Elevated bile acid levels tell your veterinarian that your dog has a significant problem with his or her liver. But it does not provide any information about the underlying cause of the liver problem. If your dog has elevated bile acid levels, your veterinarian will likely recommend additional testing or referral to an internal medicine specialist.
Imaging
Your veterinarian may also recommend some liver imaging. In general, X-rays and ultrasound are the two most common types of imaging offered in veterinary medicine. While X-rays are a useful tool for many issues, they have limited ability to evaluate the liver.
An abdominal ultrasound is much more useful in this regard. An ultrasound can evaluate for masses or nodules in the liver and can also assess the gallbladder for signs of infection, gallstones, or a mucocele. Plus, ultrasound can help determine if there might be other medical conditions like pancreatitis or Cushing’s disease that are causing a high ALP.
Liver sampling
One limitation to ultrasound is that while it can determine if the liver looks abnormal, it cannot definitively pinpoint the underlying cause of masses, nodules, or other abnormalities. Some nodules are benign changes, while others represent cancer. There may be clues on ultrasound that a mass or nodule is benign or malignant. But to know for sure the vet must take a sample of the liver. The two ways to sample the liver are fine needle aspiration or biopsy.
Fine needle aspirate
If your veterinarian finds nodules, masses, or other liver abnormalities, he or she may recommend a fine needle aspirate as the next diagnostic step. To perform an aspirate, your veterinarian will use an ultrasound probe to guide a small needle into the area of concern in the liver. Once the vet gathers the cells in the hub of the needle, he or she will squirt them onto a glass microscope slide. Then your vet will submit the slide to a veterinary pathologist for review.
In veterinary medicine we often start with fine needle aspirates over biopsies. This is because this testing is less expensive, less invasive, and the vet can do it while your dog is awake or with just mild sedation. The drawback of aspirates is that they do not always yield a diagnosis. If results are inconclusive, the vet may still recommend a liver biopsy.
Liver biopsy
A liver biopsy is the most definitive way to determine the underlying cause of liver enzyme elevations. However, it is more invasive than many of the other tests. To perform a liver biopsy, the vet will remove a small piece of the liver and submit it to a veterinary pathologist. Your vet may obtain the sample through an open abdominal surgery or laparoscopic surgery. Alternatively, your vet may use a large needle tool (i.e. the Tru-cut biopsy technique) which is significantly bigger than the needle for a fine needle aspirate.
Unlike a fine needle aspirate, which your vet can do on an awake dog, the vet will always perform the biopsy under general anesthesia. Although it may raise the question in some dog parents’ minds of “Is my dog too old for anesthesia,” a biopsy can be a very useful tool. It allows the vet to submit an actual chunk of liver tissue for evaluation. This can give a clearer idea of what is going on in the liver than a fine needle aspirate can.
Since biopsies are a more aggressive test, they may not be warranted in cases of mild or even moderate ALP elevations where the dog isn’t symptomatic and/or doesn’t have elevations in other liver enzymes. However, every dog and every case is unique. Your veterinarian will take your furry family member’s medical history, exam findings, and full lab work results into account when making his or her recommendations.
Back to my patient, Sampson
I am sure at this point you are wondering what happened to Sampson. We did perform full lab work, which aside from the ALP elevation, was beautifully normal. Apart from his sore tooth, Sampson was his normal squirrel-chasing self. He was energetic and had a great appetite.
We knew that his tooth was uncomfortable. Together his mom, Sarah, and I decided it was best to go ahead with his dental procedure. I am happy to report that the procedure went great. Sampson recovered uneventfully and is back to enjoying his crunchy dog biscuits and even the occasional stick (although sticks are not on my list of safe chew toys for dogs).
We rechecked lab work a month after his procedure and the ALP elevation was still there. Since Sarah is the proactive type, we decided to schedule an ultrasound for Sampson. The radiologist reported changes in the appearance of his liver that looked consistent with benign nodular hyperplasia, which was good news
I let Sarah know that benign nodular hyperplasia is very common condition in many senior dogs. It causes benign nodules to form in the liver and a mild to moderate ALP elevation without an elevation in the ALT. Changes on ultrasound can make the radiologist suspect this condition. But ultimately it would take a liver biopsy to rule out more nefarious causes of nodules.
After weighing the pros and cons, Sarah decided to continue monitoring for now. Sampson will come back in a month to monitor his ALP value. And then in a few more months he will have another ultrasound. I have a hunch that this is just going to be a blip on the radar for good old Sampson, and that the local squirrels won’t be able to rest anytime soon.
Talk to your vet
If like Sampson, your dog’s blood work showed a high ALP level, the best thing you can do is have an in-depth conversation with your veterinarian. Sometime being presented with all the different diagnostic options can feel a bit overwhelming. But at the end of the day, you and your trusted vet should be able to work together to create a plan for your dog—be it a “watchful waiting” approach or further diagnostics—that you feel confident about.
Hopefully, the elevated ALP will turn out to be nothing significant for your senior dog. But even if it does indicate a more serious problem, remember that your dog has a great ally in you and your veterinarian. Together, you can tackle whatever the future brings and keep making memories in the process.
Has the vet ever found a high ALP level in your senior dog’s blood work?
Please comment below to share your dog’s story.
Dr Buzby,
Thank you for having this site – it has helped me a lot while I research and cope with my dogs liver issues. To start, in 2022 her ALP was 416, March of 2024 – 2059, July 2024 – 2225 and now in October 2024 – 2400. My Stacey shows no signs of any other issues and other liver numbers are all good. We gave Denamarin for 2 months and sadly ALP rose. We are now trying Hepato TruBenefits and will retest blood work in 6 months along with my vet suggested ultrasound. Is there anything you can add to what I have or suggest?
Hi MaryAnn,
I am sorry your pup is having these ongoing issues with an elevated ALP. I understand your concern and think it is great you are searching for advice. An abdominal ultrasound would be a great next step and may offer the answers needed to find a clear path forward. Also, if testing has not been done for tick borne diseases that may be helpful as well. Wishing you and your girl all the best of luck and keep up the good work!
ALP is up again.now at 3315 after the Hipato. ALT and AST remain normal. I am leaning towards the ultrasound now. Stacy shows no signs of slowing down at all. any opinion that you can share?
Hi MaryAnn,
I am glad Stacy seems to be feeling well and has maintained her quality of life. I still think the ultrasound is a good idea and may offer the answers you seek. Don’t forget you can always ask for a consultation with an internal medicine specialist if needed. I will continue to keep you and Stacy in my thoughts as you navigate this difficult path.
Hi Dr,
our 11 years old golden retriever has started to loose his back legs since February 2024.
ran blood test and found alp quite high.
ALB/GLOB : 0,8
S.G.P.T. S.G.P.T. (cinétique uv) : 70 U/L (23-212)
ALKP : 1091 U/L
GGT : 11 U/L (0-11)
The vet did a stim test and said the results were not obviously to say if it was Cushing or not ( T1 : 151 T2 : 752 )
We then did an ultrasound, nothing is showing, he is actually in pretty good shape.
he has lost a lot of muscle in his back legs and loosing strength, struggling to get up, will stop and just collapse if we walk too far.
we are waiting for his results as we did a myeloscan yesterday and his blood test had reached 1600 ALKP
Spinal fluid taken for test too, we just don’t know what’s wrong with him.
Appreciate the great article, thanks for sharing this knowledge.
regards
Hi David,
I am sorry your senior guy is facing this unknown condition, and I understand your concern. It sounds like your vet is being very thorough with testing. I hope you will get some answers soon. Praying for a clear path forward and many happy days ahead for your sweet boy. Bless you both.
Our 13 year old Havanese has an elevated ALP that jump by over 400 points to 682 in the last three months. She is panting, but was on prozac for anxiety. She seems normal other than urinating often, but we got her from a breeder and our girl had four litters with 28 puppies. That’s a lot of pressure on a very small bladder and like human women, we think her bladder is just weaker from her pregnancies. We also looked up side effects of prozac and one of them is panting. Our vet wants to do a complicated 8 hour test where we have to leave the dog there, and/or an abdominal ultrasound. I think at her age, she would stress at staying at the vet all day and we should just retest in a few months. We also don’t think the prozac is worth it and believe it may be worsening her panting. I would love your thoughts on the prozac side effects and when to take a wait-and-see approach given age and ALP levels. Thank you in advance for your time 🙂
Hi Lori,
I am sorry your senior girl is dealing with these worrisome symptoms. From what you mentioned, it sounds like your vet is suspicious of Cushing’s disease and is wanting to test for it. I think this is a good idea. All of the symptoms you listed can be associated with Cushing’s. I understand your concern with the stress that can come from being in the clinic all day. If you decide to forgo testing and would rather pursue palliative care, that is ok. Here is a link to another article with more information: Cushing’s Disease in Dogs: Symptoms, Diagnosis, Medications
I would not be worried about Prozac causing panting and would use it if your girl is truly dealing with uncontrolled anxiety. I do wonder if some of her anxiety behaviors could be caused by Cushing’s or another underlying medical issue that has not been diagnosed yet. Praying for answers and a clear path forward. Wishing your sweet girl all the best.
Hi, our 10 year old Wire Haired Fox Terrier has been lethargic so the vet ran bloods and found his ALP to be over 700. A CT scan revealed a growth on the spleen which looks benign but we can’t be sure and also gallstones. He has been taking Desitolit and Hepatosyl and the ALP has reduced by 24 % to in the 600s. We are having bloods again in 60 days. Is this ALP level very high I have seen some results of in the thousands on this thread? Also could the gallstones be causing raised ALP? Can you suggest food to suppprt liver health?
Hi Jane,
I am sorry your senior guy is facing these worrisome issues with his liver, gallbladder, and spleen. I understand your concern and think it is good you are searching for advice. While his ALP is not the highest I’ve ever seen, it does need to be taken seriously. With the abnormalities that were found on ultrasound, I would highly recommend you consider asking for a consultation with an internal medicine specialist. Gallstones can definitely affect the liver but there could be so much more contributing to this situation. Hoping you can get the answers you need to find a clear path forward with treatment. Praying for healing and a positive outcome for your sweet boy.
My 13 year old Australian Cattle Dog mix Maggie hasn’t been feeling well for the past two weeks, we have been back and forth to the vet. They say she has pancreatitis and her ALP levels are at 1881 which are a little higher than they were in January when we did a test for Cushing (which was negative). She isn’t keeping down any food, she is staying hydrated. We have tried Panoquell injections, entyce to eat, and Cerenia for nausea. Nothing seems to work. An x-ray showed an enlarged liver and we were on Denamarin but they vet took her off of it to focus on the pancreatitis. All of her other lab work is normal. We just aren’t sure of the best road forward. She won’t eat anything!
Dear Katelyn,
I am sorry Maggie isn’t feeling well and you are struggling to maintain her nutrition. It sounds like you are doing everything you can, and I am not sure of other advice to offer. Some dogs benefit from a probiotic like Purina’s FortiFlora. Restoring gut health can do amazing things. Hoping your girl can continue to fight and praying she can make a full recovery. Feel free to leave an update and let us know how things are going, if you have a chance.
My 7.5 yo border collie fell sick the end of May. After two blood transfusions and a whole host of medication at the ER she made it out with a diagnosis of IMHA. She was on the usual med cocktail of Cyclosporine (Atopica), Prednisone, Plavax, etc. After two weeks her red blood count was still hovering in the mid-20s, so not great and the Vet thought she should be doing better but we held off on adding Azathioprine to the mix. Fast forward two weeks to the beginning of July, she fell ill with what we assume was a liver infection – elevated liver enzymes, weak, lethargic, vomiting and terrible diarrhea, but red count number in the low 30s so her anemia wasn’t the problem. IV antibiotics and a three day outpatient hospital stay and she was getting better again. Two weeks later, she is still not wanting to eat and elevated liver numbers, we experiment and take her off cyclosporine (still on prednisone and plavax)… and she’s great! Energy levels are up, her behavior returned to normal, eating like a horse, we think she’s on the right path but when we get her red blood numbers back yesterday, she’s at 24.5 – devastating. Because of her elevated liver numbers we’ve just started her on Mycophenolate to see if we can get her red blood count back up and her anemia under control. If you have any insights on this progression I would love to hear as we’re grasping at straws now.
Dear Holly,
I am sorry your girl has been through so much over the last few months. I understand your concern and applaud you for taking such an active role in advocating for her health and well-being. Your vet is already doing everything I can think of to try and balance these two different issues. If they are not consulting with an internal medicine specialist on this case then that is something you could discuss. I hope your pup can keep fighting and pray she will stabilize. Wishing you and your sweet girl all the best.
My 6.28 lb 12 year old long haired chihuahua’s ALP was 194 and her Cholestrol was 347. She hasn’t been interested in food. No vomiting but had small soft slimy stool before I took her in. Her whole life she’s been healthy and there were never any concerns until around when she was 7 we spayed her cause she was producing milk. But other than that she has been well. Her energy levels are like any senior dogs but my doctor didn’t really do much when finding out her high values. She told me the possibilities but she’s having me wait 2 days and if it doesn’t get better then we would want to do X-rays. But my concerns right now is getting her to eat and drink water which today would be the 3rd day, we’ve tried many different things like white rice, kibble, wet food, treats. What can you recommend for now I’m very concerned that she isn’t eating. And also why does her appetite decrease?
Noemi,
I understand your concern for your senior girl, and I am sorry she is unwell. Unfortunately, without examining her myself, it is hard to make specific conclusions or recommendations. You can ask your vet about an appetite stimulant, and they may have some critical care food that may be more appealing to her during this time. If you want to proceed with testing, be honest with your vet and make your wishes known. Hoping for quick answers and a clear path forward. Bless you and your sweet girl.
my mixed terrior has an ALP of 457 Baxter (my fur baby) his glucose 123, ALT 48, BUN/ Creat Ratio 23.3
protien 7.6, BUN 11.6. our vet isn’t sure what is wrong yet. Baxter came home with a different personality after his teeth cleaning and loosing..just moping around but still wants to eat soft food. but no interest in his doggy sister or brother and just laying by himself. I have to give him medicine which makes him not like me at this time either. 😂
Hi Pamela,
I am sorry Baxter’s lab work is showing some abnormalities, and I understand your concern with his recent change in personality. I hope your vet will be able to continue the investigation and get the answers you need. Praying for a clear path forward and quick results. Best wishes to you and your sweet boy.
Hi,
My 8.5 year old hound mix rescue recently had 11 teeth extracted a few due to periodontal disease and an abscess. Her pre-anesthesia blood work came back with a High ALP 2136 and a slightly high ALT 127. She has been on Denamarin for about 2.5 weeks and just had a recheck. The ALT went down but the ALP went up a few digits. She is acting fine. Eating, running, sleeping well. It’s very hot in NJ. I do notice she is urinating more but not sure if it’s because shes drinking more from the heat? Sometimes asks to go out but doesn’t go. My vet is thinking Cushings but wants her to come in for an abdominal ultrasound. Does this sound like the next step? I am so worried! Is all of this information super concerning? Thank you so much!!
Hi Lori,
I understand your concern for your senior girl and think it is great your vet is taking things so seriously. An abdominal ultrasound sounds like a great next step and will help to get a visual on the physical structure of the liver. I wouldn’t be too worried at this point. There could be an easy way to get things back on track. Hoping for answers and a clear path forward with treatment. Wishing you both all the best and praying for healing for your sweet girl.
Thank you for this great article! My vet just told me my almost 10yo dog Daisy has ALP of 227 and 6 months ago it was 228. She’s prescribing Denamarin and we’ll retest in 30 days. Your article has reassured me that the results are no reason to panic. Thanks again
Hi Kristen,
I am glad you were able to find some comfort and reassurance from the article. I think the Denamarin is a great idea. Hoping Daisy will respond favorably and praying for improved results on her lab work next month. ♥
Hey, I have a female Siberian husky, 10 years old, 71lbs (overweight). She had surgery for pyometra May 11th, 2023. I did pre check up blood work and her ALT was 95 and her ALP was 298. They did a biopsy of the liver while in the surgery due to a spot on the liver. The biopsy results stated the spot was due to the sepsis of the pyometra.
May 26th, 2023 My dog got her staples removed and I redone her liver test. ALT was 186 and her ALP 269. The vet said it wasn’t nothing to worry about due to how sick she was with the pyometra.
June 28th, 2024 a year later I got a wellness check and went ahead and redone the liver test. ALT was 205 and her ALP was 1,160. Which is significantly higher than what it was a year prior.
I haven’t noticed any signs that are unusual with my dog besides her not having as much energy as she use to and sleeps a lot. She is a scared dog as well which lead me to Cushing disease but she did not show any symptoms of this besides having anxiety. I also did notice how much glucosamine she was receiving when adjusting her diet and once I stopped the supplement 4 days ago I’ve notice a drastic difference. She no longer hides, she gets on the bed and looks out the window, no longer runs on loud noises, she seems to want to go outside more and be around the family, more barking and howling. Just overall more energy and looks happy. Before she looked tired all the time and possibly in pain or sad.
May 26th, 2023 I put her on Dasuquin Advanced just for the extra joint support. My dog food (Merrick salmon and sweet potatoes) has 400mg of glucosamine and chondroitin sulfate 400mg and the supplement I give daily has 900mg of glucosamine and 350mg or chondroitin sulfate. I feed her about a cup and a half a day plus one supplement in the evening.
With this being said I wonder if the to much glucosamine and chondroitin sulfate could have caused these elevation in her liver?
Hi Zoiee,
I understand your concern for your girl, and I agree what you describe is worrisome. I have never known these supplements to cause an issue except in an extreme case where a dog ate an entire bottle in one sitting. Most of the research I looked through said dogs were given close to 2000mg per pound each day for 12 months without any issue. So, a 10-pound dog would have received 20,000mg each day in the study with so adverse effects. Of course, some dogs don’t follow the rules and I can’t say for sure that the glucosamine didn’t cause this issue for your pup. Ultimately you have to trust your intuition as you know your girl better than anyone. It may be time to do some more in-depth investigation such as abdominal ultrasound or advanced lab work. Hoping you can get the answers you need to ensure your pup remains happy and health for as long as possible. Wishing you all the best. Bless you and your sweet girl.